Karim Khan (Persian: كريمخان, also transliterated as Karīm Khān) is a Persian name. It may refer to:

• Muhammad Shah II (r. 1442–1451), born Karim Khan, ruler of the Gujarat Sultanate in India
• Karim Khan Zand (1705–1779), founder of the Zand dynasty
• Karim Khan Sadiq (born 1984), Afghan cricketer
• Karim Ahmad Khan (born 1970), British Chief Prosecutor of the International Criminal Court
• Karim Khan Kermani (1810–1873), Shia Islamic scholar
• Abdul Karim Khan (1872–1937), Indian singer
• Abdal-Karim Khan Astrakhani (died 1520), Khan of Astrakhan
• Prince Karim Khan, 20th-century Balochi noble
• Abdul Karim Khan (Yarkand), 16th-century ruler of Yarkand Khanate
• Karim M. Khan (born 1960), a Canadian/Australian sport and exercise medicine physician

• Arg of Karim Khan, castle in Shiraz
• Karim Khan Zand Boulevard, in Shiraz
• Karim Khan, Iran, village in Razavi Khorasan Province
• Shurabeh-ye Karim Khan, village in Lorestan Province
• Mowtowr-e Karim Khan, village in Sistan and Baluchestan Province