John Radcliffe or Radcliff may refer to:

• Sir John Radcliffe (MP, died 1441), English administrator and member of Parliament for Norfolk
• Sir John Radcliffe (MP, died 1568) (1539–1568), English member of Parliament for Grampound and Castle Rising
• John Radcliffe (St Albans MP) (1738–1783), English politician
• John Q. Radcliffe (1920–2001), Wisconsin State Assemblyman

• John Radcliffe (physician, born 1650) (1650–1714), English physician
  • John Radcliffe Hospital, Oxford, named after the above
• John Netten Radcliffe (1826–1884), English epidemiologist
• John Radcliff (1848–1911), American baseball player

• John Radclive (died 1911), Canadian hangman
• John Ratcliffe (disambiguation)