Johannesburg is the largest city in South Africa. Its local government is the City of Johannesburg Metropolitan Municipality.

Johannesburg may also refer to:

• Johannesburg, California
• Johannesburg, Michigan
• Johannesburg, Wisconsin
• Johannesburg Mountain, Washington

• Johannesburg (EP), a 2016 EP by Mumford and Sons
• A 1975 single by Gil Scott-Heron

• Johannesburg Declaration, enacted in 2002
• Johannesburg (horse) (born 1999), a racehorse from Kentucky

• Schloss Johannesburg (disambiguation) (Castle Johannesburg)
• Johannesberg (disambiguation)
• Johannisberg (disambiguation)
• Johannisburg (disambiguation)
• Witwatersrand