Jayewardene, Jayawardene or Jayawardena, is a Sinhalese surname. Notable people with the surname include:

• Amal Jayawardane, Sri Lankan historian
• A. S. Jayawardene (1936–2018), Sri Lankan economist and civil servant
• Asoka Jayawardena, Sri Lankan army officer
• Athula Jayawardane, Sri Lankan army officer
• Dilan Jayawardane, Sri Lankan American engineer
• Dommie Jayawardena (1927–1979), Sri Lankan actor and singer
• Eugene Wilfred Jayewardene (1874–1932), Ceylonese lawyer and judge
• Harry Jayawardena (born 1942), Sri Lankan businessman
• Hector Alfred Jayewardene (1870–1913), Ceylonese lawyer and politician
• Hector Wilfred Jayewardene (1916–1990), Sri Lankan lawyer
• J. R. Jayewardene (1906–1996), Sri Lankan politician
• Jayalath Jayawardena (1953–2013), Sri Lankan physician and politician
• John Adrian St. Valentine Jayewardene (1877–1927), Ceylonese lawyer and judge
• Kasun Kalhara Jayawardhana (born 1981), Sri Lankan Sinhala vocalist, guitarist, record producer
• Kumari Jayawardena (born 1931), Sri Lankan academic
• Lal Jayawardena (1935–2004), Sri Lankan economist and diplomat
• Lucky Jayawardena (1955–2025), Sri Lankan politician
• Mahela Jayawardene (born 1977), Sri Lankan cricketer
• N. U. Jayawardena (1908–2002), Sri Lankan economist and banker
• Nalin Jayawardena (born 1957), Sri Lankan singer and vocalist
• Nuwan Jayawardene (born 1978), Sri Lankan cricketer
• Prasad Jayawardene (born 1980), Sri Lankan cricketer
• Prasanna Jayawardene (born 1979), Sri Lankan cricketer
• Ranil Jayawardena (born 1986), British politician
• Ray Jayawardhana, Sri Lankan academic
• Sahan Jayawardene (born 1990), Sri Lankan cricketer
• Sarath Jayawardene (born 1969), Sri Lankan cricketer
• Theodore Godfrey Wijesinghe Jayewardene (1872–1945), Ceylonese engineer and politician
• Thesara Jayawardane, Sri Lankan actress
• Tony Jayawardena (born 1978), British actor

• All pages with titles containing Jayawardana
• All pages with titles containing Jayawardane
• All pages with titles containing Jayawardena
• All pages with titles containing Jayawardene
• All pages with titles containing Jayawardhana
• All pages with titles containing Jayewardena
• All pages with titles containing Jayewardene