In enzymology, an inosine nucleosidase (EC 3.2.2.2) is an enzyme that catalyzes the chemical reaction
- inosine + H2O D-ribose + hypoxanthine
Thus, the two substrates of this enzyme are inosine and H2O, whereas its two products are D-ribose and hypoxanthine.
This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is inosine ribohydrolase. Other names in common use include inosinase, and inosine-guanosine nucleosidase. This enzyme participates in purine metabolism.
References
- Koch AL (November 1956). "Some enzymes of nucleoside metabolism of Escherichia coli". The Journal of Biological Chemistry. 223 (1): 535–49. PMID 13376622.
- Tarr HL (March 1955). "Fish muscle riboside hydrolases". The Biochemical Journal. 59 (3): 386–91. PMC 1216255. PMID 14363106.
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