I Spy or iSpy may refer to:

• I spy, a guessing game
• Industrial Spy: Operation Espionage, also known as I Spy, a squad-based tactical strategy game

• I-Spy (Michelin), a series of spotter's guides for children, 1950s onwards
• I Spy (Scholastic), a 1990s series of picture books by Jean Marzollo and Walter Wick

• I Spy (2002 film), a film starring Eddie Murphy and Owen Wilson
• I Spy, an episode from the BBC children's show Balamory
• I Spy (1934 film), a British film
• I Spy (1955 TV series), a TV series starring Raymond Massey
• I Spy (1965 TV series), an American television series starring Robert Culp and Bill Cosby
• I Spy (2002 TV series), an HBO Family series based on the picture books
• "iSpy" (Modern Family), the 14th episode of the fifth season of U.S. television series Modern Family

• I Spy (band), a Canadian band
• "I Spy" (Erica Baxter song), a 2006 song from Through My Eyes
• "iSpy" (Kyle song), a 2016 song by Kyle featuring Lil Yachty
• "I Spy", a song by Dead Kennedys from the album Bedtime for Democracy
• "I Spy", a song by Pulp from Different Class and the Mission: Impossible soundtrack

• Eye Spy (disambiguation)