Highway I–16, split into 3–I–16 and 4–I–16, is a bypass of the Circuito Sur (I–2), going from Jagüey Grande to Real Campiña in Cuba. It is the main road of the towns of Australia, Playa Larga, Playa Girón, and Covadonga.

During the Bay of Pigs Invasion, American forces mostly had power and were mostly fighting on the road of Covadonga (4–I–16) and the road of Yaguaramas (4–I–22).^[1] After the Americans left, the road looked like a “dystopian film”, with a bus seen on fire while heading into the town of Covadonga.^[2]

In March 2022, the migration of the Red land crab in the region led to a dangerous hazard on the road and anyone driving on it, with the 30 kilometer stretch between the towns of Playa Larga and Playa Girón being the worst, said by an alert by the Municipal Assembly of People's Power of Ciénaga de Zapata.^[3]

The I–16 starts as 3–I–16 in Jagüey Grande, Matanzas Province, from the Circuito Sur (3–I–2) which goes south to an at-grade intersection with the Autopista Nacional (National Motorway), and keeps going south into the towns of Australia and Playa Larga, in which it reaches the southern coast of Cuba in the Bay of Pigs, where it then follows the coastline going southeast until the town of Playa Girón. In Playa Girón, the I–22 highway also begins, in the same route of the I–16, which both goes north to the town of Helechal and later San Blas, where they split at a y-junction, with the I–16 going north and I–22 going east. After this, the road goes into Cienfuegos Province, where it turns into the 4–I–16, and into the town of Covadonga (officially Antonio Sanchez), where it turns northeast to the town of Real Campiña, back at the Circuito Sur (now 4–I–2).^[4][5][6]

Municipality	Location	km	mi	Destination[4][5][6]	Notes
Jagüey Grande	Jagüey Grande	0	0	3–I–2 (Circuito Sur / Calle 58)	Continues as Calle 15 (Calle Reyes) northbound, and starts from Calle 13 (Calle Cespedes) southbound
		1.27	0.79	Jagüey Grande Beltway
	Jagüey Grande town limits	1.75	1.09	A1 (Nacional) – Havana, Santa Clara	Exit name “Jagüey Grande” and “Playa Larga” on the A1
	Australia	2.91	1.81	?	Major one way street without a name on OpenStreetmap
Ciénaga de Zapata		20.28	12.6	Service center La Boca
	Playa Larga	29.50	18.33	Calle 1ra	Western terminus of 4 lane section with median
		30.26	18.80	Policlincio Playa Larga
		30.43	18.91	Return	Return roundabout with itself
		31.24	19.41		Western terminus of 4 lane section with median
		33.18	20.62	Road to Soplillar
		62.74	38.99	?	Major 4 lane street without a name on OpenStreetmap
	Playa Girón	63.68	39.57	Aerodromo Playa Girón
		64.18	39.88	Calle 10 – Mueso de Playa Girón
		64.55	40.11	3–I–22 / Road of Caleta Buena / Playa Los Cocos Road	Western terminus of concurrency with 3–I–22
	Helechal	72.55	45.08	Road of Cayo Ramona
	San Blas	78.79	48.95	3–I–22	Y intersection; Eastern terminus of concurrency with 3–I–22; Western terminus of unpaved section
Ciénaga de Zapata - Aguada de Pasajeros municipal border		88.43	54.95	3–I–16 / 4–I–16	Western terminus of 3–I–16; Eastern terminus of 4–I–16; Eastern terminus of unpaved section
Aguada de Pasajeros	Covadonga	95.10	59.09	Road to the Antonio Sanchez Sugar Mill
		97.49	60.58	?	Unnamed major street on OpenStreetMap
	Real Campiña	108.49	67.41	4–I–2 (Circuito Sur)