Hesperia or Hesperian may refer to:

• The Hesperian, a geologic system and time period on the planet Mars
• Hesperian Massif, the pre-Mesozoic core of the Iberian Peninsula in western Europe

• Hesperia (journal), an academic journal of Classical archaeology
• Hesperia (mythology), various people and places in Greek mythology
• Hesperia (poem), 1867 book-length verse epic by Richard Henry Wilde

• Hesperia, ancient name for both the Iberian and the Italian Peninsula, used by both the Greeks and the Romans

• Hesperia, California, a city in the United States
• Hesperia, Iowa, a former name for Burnside, Iowa, an unincorporated community in the United States
• Hesperia, Michigan, a village in the United States

• 69 Hesperia, an asteroid
• Hesperia Planum, a region of Mars

• Hesperia Hotels, Spanish hotel chain owned by NH Hoteles group
• Hesperian College, former name of Chapman University, Orange, California, U.S.
• Hesperian Health Guides, an American NGO
• Hesperian Press, an Australian publisher based in Perth

• Hesperia (actress) (1885–1959), Italian actress
• Hesperia (butterfly), a genus in the skipper family, Hesperiidae
• Hesperian, part of the common name for many species of snails in the genus Vespericola, such as the Santa Cruz hesperian
• USS Hesperia (AKS-13), a general stores issue ship

• The Hesperian Harp, a shape note tunebook published in 1848
• Hesperides (disambiguation)