HBC or HbC may refer to:

• Halton Borough Council, England
• Hellenic Broadcasting Corporation, the state-owned radio and television broadcaster for Greece
• Hokkaido Broadcasting, Japan
• Houston Boychoir, Texas, US
• HSBC Bank Canada
• Hudson's Bay Company, New York City and Toronto
• Hummelstown Brownstone Company, US

• Harvard Boxing Club, a student organization at Harvard University, US
• HB Chartres, a French association football club
• Hyderabad Bicycling Club, India

• Hemoglobin C (HbC), an abnormal hemoglobin
• Hexabenzocoronene, a polycyclic aromatic hydrocarbon
• Hormonal birth control, a contraceptive
• Human-based computation, a computer science technique
• High breaking capacity, a type of electrical fuse
• HBC, a grade of hexagonal boron nitride

• Haebangchon, a neighborhood in Seoul, South Korea
• Homebrew Channel, application for Nintendo Wii
• Harvey's Bristol Cream, a type of wine
• Head Ball Coach, nickname of retired college football coach Steve Spurrier
• Helena Bonham Carter (born 1966), actress
• Historically black college (see HBCU).

• Historically black colleges and universities (HBCU)
• HSBC (disambiguation)