Great Schism may refer to:
- East–West Schism, between the Eastern Orthodox Church and the Roman Catholic Church, beginning in 1054
- Western Schism, a split within the Catholic Church lasting from 1378 to 1417
See also
- Schism, a division between people, usually belonging to an organization, movement, or religious denomination
- Shia–Sunni relations, their division traces back to a Sunni–Shia schism
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