5'-Guanylyl imidodiphosphate (GDPNP) is a purine nucleotide. It is an analog of guanosine triphosphate in which one of the oxygen atoms is replaced with an amine, producing a non-hydrolyzable functional group. Guanylyl imidodiphosphate binds tightly to G-proteins in the presence of Mg2+.[2] Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase.[2] It is often used in studies of protein synthesis.[3][4]

References

  1. ^ Guanosine 5′-β,γ-imidotriphosphate trisodium salt hydrate at Sigma-Aldrich
  2. ^ a b Guanylyl imidodiphosphate at PubChem
  3. ^ Miller, J.D. & Walter, P. (1993). "A GTPase Cycle in Initiation of Protein Translocation Across the Endoplasmic Reticulum Membrane". Ciba Foundation Symposium 176 - the GTPase Superfamily. Novartis Foundation Symposia. Vol. 176. pp. 147–163. doi:10.1002/9780470514450.ch10. ISBN 9780470514450. PMID 8299417. {{cite book}}: |journal= ignored (help)
  4. ^ Connolly, T.; et al. (1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science. 252 (5009): 1171–1173. Bibcode:1991Sci...252.1171C. doi:10.1126/science.252.5009.1171. PMID 1851576. S2CID 42899156.
Allikas: http://en.wikipedia.org/wiki/Gpp(NH)p
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