In enzymology, a glucose-6-phosphate 1-epimerase (EC 5.1.3.15) is an enzyme that catalyzes the chemical reaction

alpha-D-glucose 6-phosphate beta-D-glucose 6-phosphate

Hence, this enzyme has one substrate, alpha-D-glucose 6-phosphate, and one product, beta-D-glucose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is D-glucose-6-phosphate 1-epimerase. This enzyme participates in glycolysis / gluconeogenesis.

As of late 2013, 3 structures have been solved for this class of enzymes, with PDB accession codes 2CIQ, 2CIR, and 2CIS.

• Wurster B, Hess B (1972). "Glucose-6-phosphate-1-epimerase from baker's yeast. A new enzyme". FEBS Lett. 23 (3): 341–344. Bibcode:1972FEBSL..23..341W. doi:10.1016/0014-5793(72)80311-9. PMID 11946648. S2CID 19331275.