George Chamberlain may refer to:

• George Chamberlain (bishop) (1576–1634), Roman Catholic bishop of Ypres
• George Chamberlain (MP), member of parliament for Woodstock
• George C. Chamberlain (1837–1896), Minnesota state representative
• George E. Chamberlain (1854–1928), American politician who served as governor and United States Senator from Oregon
• George Henry Chamberlain (1862–1943), American politician and lawyer from Ohio
• George Agnew Chamberlain (1879–1966), American novelist and diplomat
• George Philip Chamberlain (1905–1995), RAF air vice marshal
• George Richard Chamberlain, American actor and singer

• SS George Chamberlain, a World War II US Navy Liberty ship
• George D. Chamberlain High School, Tampa, Florida, US

• George Chamberlin (1846–1928), Norfolk businessman
• All pages with titles containing George Chamberlain