Frustration is an emotional response. It may also refer to:
- Frustration of purpose, in contract law
- Frustration Ridge, Churchill Mountains, Antarctica
- Frustration Dome, Mac. Robertson Land, Antarctica
- Geometrical frustration, in mathematics and physics
- "Frustration", a song by Soft Cell
- Frustration (solitaire), a single-player card game
- Frustration!, a board game
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