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English: Alignment of partial ZPA Regulatory Sequence (ZRS) in vertebrates show increased substitutions in advanced snakes compared to earlier basal snakes. Genomes were downloaded from the UCSC Genome Browser and GigaDB, and orthologous ZRS enhancer sequences were obtained by mapping the mouse sequence to the other genomes with BLAST in Kvon et al [1].
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  1. Kvon EZ, Kamneva OK, Melo US, Barozzi I, Osterwalder M, Mannion BJ (2016). "Progressive Loss of Function in a Limb Enhancer during Snake Evolution.". Cell 167 (3): 633-642.e11. DOI:10.1016/j.cell.2016.09.028. PMID 27768887. PMC: 5484524.

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ZRS Alignment Figure

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2 May 2022

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