Exchange Hotel may refer to:

Alphabetical by state, then town

• Exchange Hotel (Balmain), in Sydney, New South Wales
• Exchange Hotel, Laidley, heritage-listed in Queensland
• Exchange Hotel, Mossman, heritage-listed in Queensland
• Exchange Hotel, Kalgoorlie, heritage-listed in Western Australia

Alphabetical by state, then town

• Exchange Hotel, Montgomery, in Alabama
• Exchange Hotel (San Diego, California)
• Exchange Hotel (Milton, Florida), listed on the National Register of Historic Places (NRHP) in Santa Rosa County
• Exchange Hotel (Cardington, Ohio), NRHP-listed in Morrow County
• Exchange Hotel (Sandusky, Ohio), NRHP-listed in Sandusky
• Exchange Hotel (Gordonsville, Virginia), NRHP-listed
• Exchange Hotel (Richmond, Virginia)

• Royal Exchange Hotel, Brisbane, heritage-listed in Brisbane, Queensland, Australia