The enzyme ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) catalyzes the chemical reaction

ethanolamine phosphate + H₂O acetaldehyde + NH₃ + phosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming). Other names in common use include O-phosphoethanolamine-phospholyase, amino alcohol O-phosphate phospholyase, O-phosphorylethanol-amine phospho-lyase, and ethanolamine-phosphate phospho-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

• Fleshood HL, Pitot HC (1970). "The metabolism of O-phosphorylethanolamine in animal tissues. I O-phosphorylethanolamine phospho-lyase: partial purification and characterization". J. Biol. Chem. 245 (17): 4414–20. doi:10.1016/S0021-9258(19)63811-1. PMID 5498429.
• Jones A, Faulkner A, Turner JM (1973). "Microbial metabolism of amino alcohols. Metabolism of ethanolamine and 1-aminopropan-2-ol in species of Erwinia and the roles of amino alcohol kinase and amino alcohol o-phosphate phospho-lyase in aldehyde formation". Biochem. J. 134 (4): 959–68. doi:10.1042/bj1340959. PMC 1177904. PMID 4357716.