Edmond J. Safra Synagogue can refer to:

• Edmond J. Safra Synagogue (Brooklyn), a synagogue under construction in Brooklyn along Ocean Parkway & Avenue U.
• Edmond J. Safra Synagogue (Manhattan), a synagogue located along 63rd Street in Manhattan near Central Park.
• Edmond J. Safra Synagogue (Florida), a synagogue located near Miami, Florida.
• Edmond J. Safra Synagogue, located within the European Jewish Center, in Paris, France.
• Edmond J. Safra Grand Choral Synagogue, or more commonly known as the Grand Choral Synagogue of Saint Petersburg, in Saint Petersburg, Russia