Desta may refer to:

• Aida Desta (1927–2013), Ethiopian princess
• Araya Desta (born 1945), Eritrean diplomat
• Asrat Desta (?–1977), Ethiopian politician
• Bereket Desta (born 1990), Ethiopian sprinter
• Hirut Desta (1930–2014), Ethiopian princess
• Gebre Kristos Desta (1932–1981), Ethiopian modern artist
• Iskinder Desta (1934–1974), Ethiopian nobility and naval officer
• Tamrat Desta (1978–2018), Ethiopian singer
• Seble Desta (1931–2023), Ethiopian princess
• Sophia Desta (1934–2021), Ethiopian princess

• Desta Asgedom (1972–1992), Ethiopian athlete
• Desta Damtew (ca. 1892– 1937), Ethiopian nobility and military personnel
• Desta Girma Tadesse (born 1987), Ethiopian female long-distance runner
• Desta Hagos (born 1952), Ethiopian painter

• Desta Global, is an Indian startup technology company
• Desta: The Memories Between, 2022 action video game by Ustwo
• Desta, PLC is one of the largest privately owned apparel manufacturers and exporters in Ethiopia.
• Desta is a defunct watch manufacturer