Deoxycytidine monophosphate (dCMP), also known as deoxycytidylic acid or deoxycytidylate in its conjugate acid and conjugate base forms, respectively, is a deoxynucleotide and one of the four monomers that make up DNA. In a DNA double helix, it will base pair with deoxyguanosine monophosphate.[1]
Medical use
Deoxycytidine monophosphate is a molecule of interest in treating genetic disorders such as thymidine kinase 2 (TK2) deficiency. In the case of TK2 deficiency, dCMP in conjunction with deoxythymidine monophosphate (dTMP) to bypass the deficiency in the TK2 enzyme.[2] Additionally dCMP is an indicator of several metabolite deficiency pathways such as UMP synthase deficiency or orotic aciduria.[3]
See also
References
- ^ "Human Metabolome Database: Showing metabocard for dCMP (HMDB0001202)". hmdb.ca. Retrieved 2024-12-10.
- ^ Garone, Caterina; Garcia‐Diaz, Beatriz; Emmanuele, Valentina; Lopez, Luis C; Tadesse, Saba; Akman, Hasan O; Tanji, Kurenai; Quinzii, Catarina M; Hirano, Michio (August 2014). "Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency". EMBO Molecular Medicine. 6 (8): 1016–1027. doi:10.15252/emmm.201404092. ISSN 1757-4676. PMC 4154130.
- ^ PubChem. "Deoxycytidine 5'-monophosphate". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-12-10.
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