De Barros may refer to:

People

• Adhemar de Barros (1901-1969), Brazilian politician
• Adhemir de Barros (b. 1942), Brazilian footballer known as Paraná (footballer)
• Adriana de Barros (b. 1976), Portuguese and Canadian illustrator, web designer, and poet
• António Thomas Santos de Barros (b. 1986), Brazilian footballer known as Thomaz (footballer)
• Bruno de Barros (b. 1987), Brazilian sprinter
• Cássio Alves de Barros (b. 1970), Brazilian footballer
• Fortunato de Barros (b. 1916), Brazilian fencer
• Henrique de Barros (1904-2000), Portuguese politician
• João de Barros (1496-1570), Portuguese historian
• João Ribeiro de Barros (1900-1947), Brazilian aviator
• Jose Acacio de Barros (b. 1967), Brazilian-American physicist and philosopher
• José Leitão de Barros (1896-1967), Portuguese film director and playwright
• Luísa de Barros, Countess of Barral ( ? - ? ), Brazilian noble
• Luiz de Barros (1893-1982), Brazilian film director, film producer, film editor, screenwriter, cinematographer, film actor, and set designer and manager
• Manoel de Barros (1916-2014), Brazilian poet
• Maria de Barros (b. ? ), Senegalese-born Cape Verdean singer
• Osvaldo Velloso de Barros (1908-1996), Brazilian footballer
• Rui Duarte de Barros (b. 1960), Transitional Prime Minister of Guinea-Bissau (2012-2014)
• Théo de Barros (b. 1943), Brazilian composer
• Viriato de Barros (b. ? ), Cape Verdean writer

Other

• Estádio Cornélio de Barros, a stadium in Salgueiro, Brazil
• Estádio Wilson Fernandes de Barros, former name of Estádio Romildo Vitor Gomes Ferreira, a stadium in Moji-Mirim, São Paulo, Brazil
• Rodovia Adhemar de Barros, a highway in the state of São Paulo, Brazil
• Tierra de Barros, a comarca in Badajoz, Extremadura, Spain