David or Dave Clarke may refer to:

• David Clarke (actor) (1908–2004), American actor
• Dave Clarke (musician) (born 1948), American singer, guitarist, and keyboard player
• Dave Clarke (DJ) (born 1968), English techno DJ
• David Clarke, a character in the TV series Revenge

• David Clarke (Australian politician) (born 1947), member of New South Wales Legislative Council
• David Clarke (sheriff) (born 1956), former sheriff of Milwaukee County
• David A. Clarke (1943–1997), founding member of the Washington, D.C. city council

• Dave Clarke (English footballer) (born 1949), English football goalkeeper
• Dave Clarke (Scottish footballer) (born 1950), Scottish football player and manager
• Dave Clarke (Canadian football) (born 1950), Canadian football player
• David Clarke Sr. (born 1952), Australian rules footballer
• David Clarke (footballer, born 1964), English footballer
• David Clarke (Paralympic footballer) (born 1970), English five-a-side footballer
• David Clarke (Australian footballer, born 1980) (born 1980), Australian rules footballer
• David Clarke (Gaelic footballer) (born 1983), Gaelic footballer

• David Clarke (English cricketer) (born 1967), English cricketer
• David Clarke (Australian cricketer) (born 1970), Australian cricketer
• Dave Clarke (hurler) (born 1971), Irish hurler
• David Clarke (ice hockey) (born 1981), English ice hockey player
• Dave Clarke (rugby league), rugby league footballer for Wales in 2004
• Dave Clarke (runner) (born 1958), British distance runner

• David Clarke (journalist) (born 1967), English lecturer and writer on UFO sightings since 2008
• David Clarke (professor), Deputy Vice-Chancellor of Bristol University
• David L. Clarke (1937–1976), English archaeologist
• David R. Clarke, material scientist and physics professor
• David J. Clarke (born 1954), professor of modern and contemporary art at the University of Hong Kong

• David Clarke (minister) (born 1946), Moderator of the Presbyterian Church in Ireland 2006
• David Clarke (priest) (1923–?), Anglican priest

• David S. Clarke (1942–2011), Australian chief executive and winemaker

• David Clark (disambiguation)