Darwin is a surname that is a modern spelling of Old English name Deorwine. Notable people with the surname include:

• Members of Charles Darwin's family:
  • Anne Darwin (1841–1851), daughter of Charles Darwin (1809–1882)
  • Bernard Darwin (1876–1961), golf writer
  • Charles Darwin (1809–1882), English naturalist and writer
  • Charles Darwin (1758–1778) physician and scientist, uncle of Charles Darwin (1809–1882)
  • Sir Charles Galton Darwin (1887–1962), physicist
  • Charles Waring Darwin (infant) (1856–1858), youngest son of Charles Darwin (1809–1882)
  • Charles Waring Darwin (soldier) (1855–1928), second cousin once removed of Charles Darwin (1809–1882)
  • Edward Levett Darwin (1821–1901), solicitor and author
  • Elinor Darwin (1871–1954), illustrator, engraver and portrait painter, wife of Bernard Darwin
  • Emma Darwin née Wedgwood (1808–1896), wife of Charles Darwin (1809–1882)
  • Emma Darwin (novelist) (born 1964), novelist
  • Erasmus Darwin (1731–1802), physician and biologist, grandfather of Charles Darwin (1809–1882)
  • Erasmus Darwin IV (1881–1915), businessman and soldier, son of Sir Horace Darwin
  • Erasmus Alvey Darwin (1804–1881), brother of Charles Darwin (1809–1882)
  • Etty Darwin, better known as Henrietta Litchfield (1843–1929), daughter of Charles Darwin (1809–1882)
  • Sir Francis Darwin (1848–1925), botanist
  • Sir Francis Sacheverel Darwin (1786–1859), physician and traveler
  • Sir George Darwin (1845–1912), astronomer and mathematician
  • Gwendoline Mary Darwin, birth name of Gwen Raverat (1885–1957), artist
  • Sir Horace Darwin (1851–1928), civil engineer
  • Ida Darwin (1854–1946), mental health campaigner, wife of Sir Horace Darwin
  • Leonard Darwin (1850–1943), soldier, politician, and activist
  • Emma Nora Darwin, birth name of Nora Barlow (1885–1989), editor and biographer of Charles Darwin (1809–1882)
  • Robert Darwin (1766–1848), physician, father of Charles Darwin (1809–1882)
  • Robert Waring Darwin of Elston (1724–1816), author of Principia Botanica
  • Robin Darwin (1910–1974), artist
  • Ursula Frances Elinor Darwin, birth name of Ursula Mommens (1908–2010), potter
  • William Erasmus Darwin (1839–1914), eldest son of Charles Darwin (1809–1882)
• Ben Darwin (born 1976), Australian international Rugby player
• Bobby Darwin, (born 1943), American baseball player
• Charles Darwin (disambiguation), several people
• Danny Darwin (born 1955), American baseball player
• Donald Victor Darwin (1896–1972) Australian road engineer
• George Darwin (footballer) (1932–2019), English footballer
• Jeff Darwin (born 1969), American baseball player
• John Darwin (disambiguation), several people
• Mike Darwin (born 1955), American writer and activist

• Darwen (disambiguation) § People with the surname Darwen
• Derwin, given name and surname
• Darwin (given name)