Colo-Colo is a Chilean men's football club based in Macul, Santiago.

Colo-Colo may also refer to:

• Colo-colo (condiment), a spicy Indonesian condiment
• Colo Colo (mythology), a rat-like creature from Mapuche mythology
• Colo-Colo (women), a Chilean women's football club
• Colo-Colo B, a Chilean men's football team
• Chilean ship Colo Colo, a list of ships
• Colocolo (tribal chief), a Mapuche leader

• All pages with titles containing Colo Colo
• Colo (disambiguation)