Cimlanod (development codes CXL-1427 and BMS-986231) is an experimental drug for the treatment of acute decompensated heart failure. It was discovered by Cardioxyl Pharmaceuticals, which was acquired by Bristol-Myers Squibb. It is a precursor of nitroxyl.[1]

Cimlanod is a prodrug of CXL-1020.[2]

A preliminary study showed efficacy in patients with class III and IV heart failure.[3] A phase II clinical trial was completed in 2016.[4]

References

  1. ^ "BMS 986231". AdisInsight. Springer Nature Switzerland AG. Retrieved 2017-05-22. Alternative Names: BMS-986231; CXL 1427; HNO Donor
  2. ^ "CXL 1020". AdisInsight. Springer Nature Switzerland AG. Retrieved 2017-05-22.
  3. ^ Zoler ML (22 May 2016). "Nitroxyl prodrug shows promise in acute heart failure".
  4. ^ Clinical trial number NCT02157506 for "A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure" at ClinicalTrials.gov
Allikas: http://en.wikipedia.org/wiki/Cimlanod
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