Cetadiol, also known as androst-5-ene-3β,16α-diol, is a drug described as a "steroid tranquilizer" which was briefly investigated as a treatment for alcoholism in the 1950s.[1][2][3][4][5] It is an androstane steroid and analogue of 5-androstenediol (androst-5-ene-3β,17β-diol) and 16α-hydroxy-DHEA (androst-5-ene-3β,16α-diol-17-one), but showed no androgenic or myotrophic activity in animal bioassays.[4] The drug was reported in 1956 and studied until 1958.[1]

Chemistry

See also: List of neurosteroids

See also

References

  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 86–. ISBN 978-1-4757-2085-3.
  2. ^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 1841. ISBN 978-3-527-30247-5.
  3. ^ Lemere F (April 1957). "New steroid hormone tranquilizing agent (cetadiol)". The American Journal of Psychiatry. 113 (10): 930. doi:10.1176/ajp.113.10.930. PMID 13402989.
  4. ^ a b Campbell CH, Sleeper HG (April 1956). "Cetadiol (5-androstene-3 16-diol) in the treatment of hospitalized alcoholics". The American Journal of Psychiatry. 112 (10): 845. doi:10.1176/ajp.112.10.845. PMID 13302491.
  5. ^ Wexler D, Leiderman PH, Mendelson J, Kubzansky P, Solomon P (April 1958). "The effect of cetadiol on delirium tremens, alcoholic hallucinosis, and alcohol withdrawal". The American Journal of Psychiatry. 114 (10): 935–936. doi:10.1176/ajp.114.10.935. PMID 13508929.
Allikas: http://en.wikipedia.org/wiki/Cetadiol
No tags for this post.