Castiglioni is an Italian surname. People with this surname include:

• Giannino Castiglioni (1884–1971), Italian artist
• Achille Castiglioni (1918–2002), Italian architect and industrial designer
• Livio Castiglioni (1911–1979), Italian architect and industrial designer
• Pier Giacomo Castiglioni (1913–1968), Italian architect and industrial designer
• Francesco Saverio Castiglioni (1761–1830), Pope Pius VIII
• Goffredo da Castiglione / Godfrey Castiglioni (died 1241), Pope Celestine IV
• St. Buono Castiglioni (818–822), Bishop of Milan
• St. Honoratus Castiglioni (568–572), Bishop of Milan
• Teresa Ciceri Castiglioni (1750–1821) was an Italian inventor, agronomist
• Arturo Castiglioni (1874–1952), Italian-American medical historian
• Camillo Castiglioni (1879–1961), Austrian financier and banker
• Consuelo Castiglioni, b. 1959, Chilean-Italian fashion designer
• Luis Alberto Castiglioni Soria, former vice president of Paraguay
• Niccolò Castiglioni (1932–1996), Italian composer and pianist

• Palazzo Castiglioni (disambiguation)
• The Castiglioni Brothers (film)
• Castigliano
• Castiglione (disambiguation)
• Castiglione (surname)
• Via Fratelli Castiglioni (street in Milan named after Achille, Livio, and Pier Giacomo Castiglioni)