In enzymology, a carboxyvinyl-carboxyphosphonate phosphorylmutase (EC 2.7.8.23) is an enzyme that catalyzes the chemical reaction

1-carboxyvinyl carboxyphosphonate 3-(hydrohydroxyphosphoryl)pyruvate + CO₂

Hence, this enzyme has one substrate, 1-carboxyvinyl carboxyphosphonate, and two products, 3-(hydrohydroxyphosphoryl)pyruvate and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating).

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QIW.

• Pollack SJ, Freeman S, Pompliano DL, Knowles JR (1992). "Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus". Eur. J. Biochem. 209 (2): 735–43. doi:10.1111/j.1432-1033.1992.tb17342.x. PMID 1330557.
• Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ (1987). "Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus". J. Bacteriol. 169 (8): 3482–8. doi:10.1128/jb.169.8.3482-3488.1987. PMC 212421. PMID 3611020.