Butch is a nickname which may refer to:

• Frederick Alan Aikman (1919–1991), Canadian World War II flying ace
• Butch Baird (born 1936), American retired PGA and Senior PGA Tour golfer
• Butch Ballard (1918–2011), American jazz drummer
• Butch Beard (born 1947), American basketball player
• William H. Blanchard (1916–1966), US Air Force four-star general
• Émile Bouchard (1919–2012), Canadian National Hockey League player and member of the Hockey Hall of Fame
• Butch Buchholz (born 1940), American former tennis player
• Mark Butcher (born 1972), English former Test cricketer
• Butch Cassidy (1866–1908), American outlaw
• Butch Davis (born 1951), American football coach
• Ronald DeFeo, Jr. (1951–2021), American murderer
• Kevin DuBrow (1955–2007), American lead vocalist of the heavy metal band Quiet Riot
• Adrian S. Fisher (1914–1983), American lawyer and public servant
• Butch Goring (born 1949), Canadian National Hockey League player
• William Edward Hanford (1908–1996), American chemist who developed the modern process for making polyurethane
• Butch Harmon (born 1943), American golf instructor and former player
• Sir Arthur Harris, 1st Baronet (1892–1984), Marshal of the Royal Air Force during the Second World War
• Butch Hartman (born 1965), American animator, writer, director, producer, illustrator and voice actor
• Butch Hartman (racing driver) (1940–1994), American stock car racing national champion
• Bob Heffner (born 1938), American retired Major League Baseball pitcher
• Butch James (born 1979), South African former rugby union player
• Butch Johnson (American football) (born 1954), former National Football League wide receiver
• John J. Lenzini, Jr. (1947–1996), American Thoroughbred horse trainer
• Butch Levy (1921–1999), American football player and professional wrestler
• Butch Lindley (1948–1990), American NASCAR driver
• Butch Lochner (1931–2010), South African former international rugby union player
• Obert Logan (1941–2003), American National Football League player
• Graeme Macdougall (born 1940), Australian former rugby union player
• Ed Mierkowicz (1924–2017), American former Major League Baseball player
• Butch Miles (1944-2023), American drummer and musician
• Butch Morris (1947–2013), American jazz cornetist, composer and conductor
• Jonathan Norton (born 1958), original drummer for the band Eels
• Edward O'Hare (1914–1943), American pilot during World War II
• Butch Otter (born 1942), American politician and former governor of Idaho
• Butch Reynolds (born 1964), American former 400-meter sprinter
• Isiah Robertson (1949–2018), American National Football League player
• Harry G. Robinson III (born 1942), American architect and professor
• Roy Sanders (National League pitcher) (1892–1950), American Major League Baseball pitcher
• Walter Schindler (1897–1991), US Navy vice admiral
• Clyde J. Tate II (born 1957), American major general and army lawyer
• Butch Vig (born 1955), American musician and producer, and drummer for the band Garbage
• Roy Marlin Voris (1919–2005), American World War II flying ace and founder of the Blue Angels flight demonstration squadron
• Bill Walker (Australian footballer, born 1942), New Zealand former Australian rules footballer
• Butch Walker (born 1969), American recording artist, songwriter, and record producer
• Ray Wilkins (1956–2018), English former football player
• Butch Wynegar (born 1956), American Major League Baseball player