Bouvardin is a bicyclic hexapeptide isolated from Bouvardia ternifolia. Its chemical formula is C40H48N6O10. It is derived from the amino acid sequence Ala-Ala-Tyr-Ala-Tyr-Tyr. It has demonstrated certain anti-cancerous activities by inhibiting protein synthesis through inhibition of 80S ribosomes (eukaryotic ribosomes).[1]

References

  1. ^ Boger, Dale L; Patane, Michael A; Zhou, Jiacheng (1994). "Total Synthesis of Bouvardin, O-Methylbouvardin, and O-Methyl-N9-desmethylbouvardin". Journal of the American Chemical Society. 116 (19): 8544–8556. doi:10.1021/ja00098a015.


Allikas: http://en.wikipedia.org/wiki/Bouvardin
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