In enzymology, a benzophenone synthase (EC 2.3.1.151) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 3-hydroxybenzoyl-CoA 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO₂

Thus, the two substrates of this enzyme are malonyl-CoA and 3-hydroxybenzoyl-CoA, whereas its 3 products are CoA, 2,3',4,6-tetrahydroxybenzophenone, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase.

• Beerhues L (April 1996). "Benzophenone synthase from cultured cells of Centaurium erythraea". FEBS Letters. 383 (3): 264–6. doi:10.1016/0014-5793(96)00265-7. PMID 8925910.