The axolotl (/ˈæksəlɒtəl/) is a critically endangered neotenic salamander that is native to Lake Xochimilco and Lake Chalco in central Mexico. The axolotl's ability to regenerate complex tissues, including limbs and spinal cord, has made it a key model organism in regenerative biology. Studies have shown that axolotl regeneration involves specific signaling pathways and gene expression mechanisms, including the role of the Pax7 gene, which is critical for both growth and regeneration (Nowoshilow et al., 2018)

Axolotl may also refer to:

• Axolotl Press, an American small press publisher that was acquired by Pulphouse Publishing in 1989
• Axolotl tanks, a fictional technology in the Dune universe created by Frank Herbert
• Double Ratchet Algorithm (formerly known as the Axolotl Ratchet), a cryptographic key management algorithm
• "Axolotl", a song by The Veils from the album Total Depravity
• the proper name of the star HD 224693
• "Axolotl", a short story by Julio Cortázar, published in his Final del juego collection
• The Old Axolotl, a digital only novel by Polish author Jacek Dukaj