Andrew Holmes or Andy Holmes may refer to:

• Andrew Holmes (army officer) (died 1814), American army officer in the War of 1812
• Andrew Holmes (soldier), U.S. army soldier accused of having committed war crimes in Afghanistan
• Andrew Holmes (activist), activist and local politician from Illinois
• Andrew Fernando Holmes (1797–1860), Canadian physician and academic
• Andrew Holmes, California National Guardsman and plaintiff in Holmes v. California National Guard
• Andrew Bruce Holmes (born 1943), Australian scientist
• Andy Holmes (1959–2010), British rower
• Andy Holmes (footballer) (born 1969), English footballer
• Andrew O. Holmes (1906–1965), Associate Justice of the Tennessee Supreme Court