Alexius I or Alexios I Komnenos (1048–1118), was Byzantine Emperor.
Alexius I may also refer to:
- Alexius of Constantinople, Ecumenical Patriarch in 1025–1043
- Alexios I of Trebizond (c. 1182–1222), Emperor of Trapezunt
- Alexis of Russia (1629–1676), second Russian tsar of the Romanov dynasty
- Patriarch Alexy I of Moscow (1877–1970), 13th Patriarch of Moscow
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