Agosterol A is a bio-active sterol which may have applications in removing multi-drug resistance in various cancers.[1][2] It was first isolated from marine sponge but has also been produced synthetically.[3]

References

  1. ^ Chen, Zhe-Sheng; Aoki, Shunji; Komatsu, Masaharu; Ueda, Kazumitsu; Sumizawa, Tomoyuki; Furukawa, Tatsuhiko; Okumura, Hiroshi; Ren, Xiao-Qin; Belinsky, Martin G.; Lee, Kun; Kruh, Gary D.; Kobayashi, Motomasa; Akiyama, Shin-ichi (2001). "Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function". International Journal of Cancer. 93 (1): 107–113. doi:10.1002/ijc.1290. ISSN 0020-7136. PMID 11391629.
  2. ^ Aoki, Shunji; Chen, Zhe-Sheng; Higasiyama, Kimihiko; Setiawan, I; Akiyama, Shin-ichi; Kobayashi, Motomasa (2001). "Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells". Japanese Journal of Cancer Research. 92 (8): 886–895. doi:10.1111/j.1349-7006.2001.tb01177.x. ISSN 0910-5050. PMC 5926837. PMID 11509122.
  3. ^ Murakami, Nobutoshi; Sugimoto, Masanori; Morita, Mari; Kobayashi, Motomasa (2001). "Total Synthesis of Agosterol A: an MDR-Modulator from a Marine Sponge". Chemistry: A European Journal. 7 (12): 2663–2670. doi:10.1002/1521-3765(20010618)7:12<2663::AID-CHEM26630>3.0.CO;2-U. ISSN 0947-6539. PMID 11465457.


Allikas: http://en.wikipedia.org/wiki/Agosterol_A
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