Accomac may refer to:

• Accomac, Virginia, a town in Virginia
  • Accomac Shire, a former county in Virginia of which the town was the county seat
• Accomac, Pennsylvania

• Accomac people, a historic Native American tribe from the Eastern Shore of Virginia

• USS Accomac, three ships of the US Navy

• Accomack County, Virginia, the current incarnation of Accomac Shire
• Plymouth, Massachusetts was built on a site identified on early maps as Accomack