ACPA may refer to:

• Aboriginal Centre for the Performing Arts, Brisbane, Australia
• Air Canada Pilots Association, former trade union in Canada
• The Arts & College Preparatory Academy, Columbus, Ohio, U.S.
• Allegheny County Port Authority, former name of Pittsburgh Regional Transit
• American Catholic Philosophical Association, U.S.
• American China Policy Association, a former anti-Communist organisation
• American College Personnel Association, a student affairs organisation in Washington D.C., U.S.
• Armenian College and Philanthropic Academy, an Armenian school in Kolkata, India
• Association of Certified Public Accountants, former name of Certified Public Accountants Association, England, U.K.

• Anticybersquatting Consumer Protection Act, a 1999 United States law
• Anti-citrullinated protein antibody, an antibody to an individual's own proteins
• Arachidonylcyclopropylamide, a synthetic agonist of the cannabinoid receptor 1
• 4,4'-Azobis(4-cyanopentanoic acid), a free radical initiator used in polymer synthesis