A52 may refer to:

• Ubiquitin A-52 residue ribosomal protein fusion product 1, a human gene

• A52 road (England), a road connecting Newcastle-under-Lyme and Mablethorpe
• A52 motorway (France), a road connecting Aubagne and the A50
• Bundesautobahn 52, a highway in Germany usually referred to as A52
• A52 motorway (Italy), a ring road around Milan
• A52 motorway (Switzerland), a road connecting Zumikon and Hinwil
• Autovía A-52 Spain, highway connecting Benavente and O Porriño

• Samsung Galaxy A52, an Android smartphone
• The A/52 audio codec, also known as AC-3 or Dolby Digital
• One of the Encyclopaedia of Chess Openings codes for the Budapest Gambit in chess
• Action 52, a video game developed by Active Enterprises