5-Hydroxycytosine is an oxidized form of cytosine that is associated with an increased frequency of C to T transition mutations, with some C to G transversions.[1] It does not distort the DNA molecule and is readily bypassed by replicative DNA polymerases.[2]
It has been shown in vitro to miscode for adenine.
5-hydroxycytosine is imperative for parallel DNA triplex formation, explaining why parallel triplexes form only at pH 6 and below.
References
- ^ Zahn KE; Averill A; Wallace SS; Doublié S (2011). "The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site". Biochemistry. 50 (47): 10350–10358. doi:10.1021/bi201219s. PMC 3280588. PMID 22026756.
- ^ Helmut Greim; Richard J. Albertini (2012). The Cellular Response to the Genotoxic Insult: The Question of Threshold for Genotoxic Carcinogens. Royal Society of Chemistry. p. 119. ISBN 9781849731775. Retrieved July 20, 2015.
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