The 2025 Coca-Cola 600, is an upcoming NASCAR Cup Series race that will be held on May 25, 2025, at Charlotte Motor Speedway in Concord, North Carolina and the 66th running of the event. It is contested over 400 laps on the 1.5-mile (2.4 km) asphalt speedway, it will be the 13th race of the 2025 NASCAR Cup Series season, as well as the second of the four crown jewel races.

The race was held at Charlotte Motor Speedway, located in Concord, North Carolina. The speedway complex includes a 1.5-mile (2.4 km) quad-oval track that was utilized for the race, as well as a dragstrip and a dirt track. The speedway was built in 1959 by Bruton Smith and is considered the home track for NASCAR with many race teams based in the Charlotte metropolitan area. The track is owned and operated by Speedway Motorsports Inc. (SMI) with Marcus G. Smith serving as track president.

• (R) denotes rookie driver.
• (i) denotes driver who is ineligible for series driver points.

Prime Video will cover the race on the television side. Adam Alexander, Dale Earnhardt Jr. and Steve Letarte will call the race from the broadcast booth. Kim Coon, Marty Snider, and Trevor Bayne will handle pit road for the television side.

Radio coverage of the race will be broadcast by the Performance Racing Network (PRN), and will also simulcasted on Sirius XM NASCAR Radio. Brad Gillie and Mark Garrow will call the race in the booth when the field raced through the quad-oval. Rob Albright will call the race from a billboard in turn 2 when the field will race through turns 1 and 2 and halfway down the backstretch. Pat Patterson will call the race from a billboard outside of turn 3 when the field will race through the other half of the backstretch and through turns 3 and 4. Wendy Venturini, Brett McMillan, and Alan Cavanna will be the pit reporters during the broadcast.