Jiří Lehečka won the men's singles tennis title at the 2025 Brisbane International, 4–1, after Reilly Opelka retired in the final.^[1] It was his second career ATP Tour title.

Grigor Dimitrov was the defending champion,^[2] but retired against Lehečka in the semifinals.

This tournament marked the return to professional tennis of former world No. 13 Nick Kyrgios after nearly two years out of competition due to a wrist injury. He lost to Giovanni Mpetshi Perricard in the first round.^[3]

	Semifinals							Final
	PR	Reilly Opelka	6	77
		Giovanni Mpetshi Perricard	3	64
								PR	Reilly Opelka	1r
									Jiří Lehečka	4
		Jiří Lehečka	6	4
	2	Grigor Dimitrov	4	4r

	First round							Second round							Quarterfinals							Semifinals
	1	N Djokovic	6	6
	WC	R Hijikata	3	3				1	N Djokovic	6	6
	Q	N Basavareddy	4	6	1				G Monfils	3	3
		G Monfils	6	4	6										1	N Djokovic	66	3
	Q	FA Gómez	5	4											PR	R Opelka	78	6
	PR	R Opelka	7	6				PR	R Opelka	711	77
		M Arnaldi	6	6					M Arnaldi	69	64
	7	A Popyrin	3	2																		PR	R Opelka	6	77
	4	F Tiafoe	77	6																			G Mpetshi Perricard	3	64
	WC	A Walton	65	3				4	F Tiafoe	4	64
		G Mpetshi Perricard	77	64	77				G Mpetshi Perricard	6	77
	PR	N Kyrgios	62	77	63											G Mpetshi Perricard	7	77
		J Menšík	77	6												J Menšík	5	65
	Q	M Kukushkin	63	4					J Menšík	6	6
		A Cazaux	4	4				LL	D Lajović	3	2
	LL	D Lajović	6	6

	First round							Second round							Quarterfinals							Semifinals
	6	A Tabilo	710	65	4
	Q	B Bonzi	68	77	6			Q	B Bonzi	2	3
		M Navone	5	67					N Jarry	6	6
		N Jarry	7	79												N Jarry	4	4
		A Rinderknech	3	4												J Lehečka	6	6
	Q	Y Nishioka	6	6				Q	Y Nishioka	2	77	4
		J Lehečka	7	6					J Lehečka	6	65	6
	3	H Rune	5	3																			J Lehečka	6	4
	8	J Thompson	3	6	6																	2	G Dimitrov	4	4r
		M Berrettini	6	3	4			8	J Thompson	7	6
		A Michelsen	6	4	712				A Michelsen	5	3
		C O'Connell	4	6	610										8	J Thompson	1	1r
		D Goffin	2	3											2	G Dimitrov	6	2
	WC	A Vukic	6	6				WC	A Vukic	2	65
	Q	Y Hanfmann	65	3				2	G Dimitrov	6	77
	2	G Dimitrov	77	6

	First round							Qualifying competition
	1	Yoshihito Nishioka	6	77
		Alex Bolt	2	64
								1	Yoshihito Nishioka	6	2	6
									Li Tu	3	6	4
		Li Tu	6	6
	10	Lukáš Klein	4	4

	First round							Qualifying competition
	2	Benjamin Bonzi	6	6
	WC	James McCabe	3	2
								2	Benjamin Bonzi	3
									Adrian Andreev	1r
		Adrian Andreev	6	3	77
	8	Tseng Chun-hsin	4	6	65

	First round							Qualifying competition
	3	Dušan Lajović	5	7	2
	WC	Casey Hoole	7	5	0r
								3	Dušan Lajović	1	64
								11	Federico Agustín Gómez	6	77
		Ugo Blanchet	6	3	5
	11	Federico Agustín Gómez	3	6	7

	First round							Qualifying competition
	4	James Duckworth	4	4
		Tristan Schoolkate	6	6
									Tristan Schoolkate	4	4
								7	Mikhail Kukushkin	6	6
		Andrea Collarini	2	4
	7	Mikhail Kukushkin	6	6

	First round							Qualifying competition
	5	Yannick Hanfmann	6	6
	WC	Jacob Bradshaw	4	2
								5	Yannick Hanfmann	77	6
								9	Richard Gasquet	64	3
	WC	Derek Pham	1	2
	9	Richard Gasquet	6	6

	First round							Qualifying competition
	6	Lucas Pouille	4	6	78
	PR	Jason Kubler	6	3	66
								6	Lucas Pouille	4	4
								12	Nishesh Basavareddy	6	6
	PR	Borna Gojo	6	64	4
	12	Nishesh Basavareddy	4	77	6