The 2022 Zagreb Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Zagreb, Croatia between 25 April and 1 May 2022.^[1]

Country	Player	Rank1	Seed
CRO	Donna Vekić	107	1
GER	Jule Niemeier	108	2
HUN	Réka Luca Jani	140	3
ARG	Paula Ormaechea	150	4
SLO	Polona Hercog	164	5
GRE	Despina Papamichail	173	6
GER	Anna-Lena Friedsam	184	7
CZE	Linda Nosková	188	8

• ¹ Rankings are as of 18 April 2022.

The following players received wildcards into the singles main draw:

• Lucija Ćirić Bagarić
• Petra Marčinko
• Lola Radivojević
• Donna Vekić

The following players received entry from the qualifying draw:

• Lea Bošković
• Živa Falkner
• Tena Lukas
• Eva Lys
• Ekaterina Makarova
• Nina Potočnik
• Antonia Ružić
• Tara Würth

• Jule Niemeier def. Réka Luca Jani, 6–2, 6–2

• Anastasia Dețiuc / Katarina Zavatska def. Lina Gjorcheska / Irina Khromacheva, 6–4, 6–7^(5–7), [11–9].

• 2022 Zagreb Ladies Open at ITFtennis.com
• Official website