Iga Świątek defeated Donna Vekić in the final, 6–3, 3–6, 6–0 to win the women's singles tennis title at the 2022 San Diego Open.^[1] It was her eighth title of the 2022 season. By winning the title, Świątek became the first player since Serena Williams in 2013 to win more than 10,000 ranking points in a single season.

This was the first WTA Tour-level event to be held in the San Diego area since 2013.^[2]

The top four seeds received a bye into the second round.

	Semifinals							Final
	1	Iga Świątek	4	6	6
	4	Jessica Pegula	6	2	2
								1	Iga Świątek	6	3	6
								Q	Donna Vekić	3	6	0
	Q	Donna Vekić	6	4	77
		Danielle Collins	4	6	62

	First round							Second round							Quarterfinals							Semifinals
								1	I Świątek	6	4	6
	LL	Q Zheng	5					LL	Q Zheng	4	6	1
		G Muguruza	0r												1	I Świątek	6	6
	PR	B Andreescu	77	4	6										6	C Gauff	0	3
		L Samsonova	61	6	2			PR	B Andreescu	4	6	3
	Q	R Montgomery	3	3				6	C Gauff	6	4	6
	6	C Gauff	6	6																		1	I Świątek	4	6	6
																						4	J Pegula	6	2	2
								4	J Pegula	6	6
	WC	C Vandeweghe	6	1	6			WC	C Vandeweghe	3	1
	PR	S Kenin	1	6	4										4	J Pegula	6	7
		M Keys	6	6												M Keys	4	5
	Q	E Perez	1	4					M Keys	6	6
	WC	L Fernandez	2	2				8	D Kasatkina	4	3
	8	D Kasatkina	6	6

	First round							Second round							Quarterfinals							Semifinals
	5/WC	M Sakkari	63	1
	Q	D Vekić	77	6				Q	D Vekić	6	6
		Ka Plíšková	6	6					Ka Plíšková	3	2
	Q	C Dolehide	3	4											Q	D Vekić	6	65	6
	LL	J Teichmann	1	62											3	A Sabalenka	4	77	1
	WC	S Stephens	6	77				WC	S Stephens	6	3	2
								3	A Sabalenka	1	6	6
																						Q	D Vekić	6	4	77
	7	C Garcia	2	64																			D Collins	4	6	62
		D Collins	6	77					D Collins	6	6
		M Trevisan	6	6					M Trevisan	2	4
	Q	C Osorio	3	4												D Collins	77	6
	Q	L Chirico	1	7	77										2	P Badosa	65	4
		A Riske-Amritraj	6	5	65			Q	L Chirico	0	3
								2	P Badosa	6	6

	First round							Qualifying competition
	Alt	Ellen Perez	6	6
	PR	Varvara Flink	1	1
								Alt	Ellen Perez	4
								10	Anna Kalinskaya	1r
		Emma Navarro	4	63
	10	Anna Kalinskaya	6	77

	First round							Qualifying competition
	2	Zhang Shuai	2	3
	WC	Robin Montgomery	6	6
								WC	Robin Montgomery	1	6	6
								7	Bernarda Pera	6	1	4
		Elisabetta Cocciaretto	63	3
	7	Bernarda Pera	77	6

	First round							Qualifying competition
	3	Zheng Qinwen	6	6
		Rebecca Marino	1	1
								3	Zheng Qinwen	6	4	63
								11	Camila Osorio	4	6	77
	WC	Madison Sieg	1	2
	11	Camila Osorio	6	6

	First round							Qualifying competition
	4	Aliaksandra Sasnovich	1	6	2
	WC	Ashlyn Krueger	6	1	6
								WC	Ashlyn Krueger	3	1
								WC	Louisa Chirico	6	6
	WC	Louisa Chirico	7	1	6
	8	Yulia Putintseva	5	6	4

	First round							Qualifying competition
	5	Kaia Kanepi	3	2
		Lauren Davis	6	6
									Lauren Davis	63	4
								12	Donna Vekić	77	6
		Elizabeth Mandlik	4	3
	12	Donna Vekić	6	6

	First round							Qualifying competition
	6	Jil Teichmann	6	77
		Carol Zhao	1	62
								6	Jil Teichmann	4	2
									Caroline Dolehide	6	6
		Caroline Dolehide	77	7
	9	Madison Brengle	65	5

• Qualifying draw
• Main draw