The 2022 Città di Grado Tennis Cup was a professional tennis tournament played on outdoor clay courts. It was the twenty-fifth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Grado, Italy between 23 and 29 May 2022.^[1]

Country	Player	Rank1	Seed
SUI	Ylena In-Albon	119	1
UKR	Kateryna Baindl	146	2
ITA	Lucrezia Stefanini	157	3
ITA	Elisabetta Cocciaretto	159	4
ITA	Sara Errani	160	5
	Anastasia Tikhonova	177	6
SUI	Stefanie Vögele	178	7
SUI	Simona Waltert	212	8

• ¹ Rankings are as of 16 May 2022.

The following players received wildcards into the singles main draw:

• Nuria Brancaccio
• Deborah Chiesa
• Sara Errani
• Angelica Raggi

The following players received entry from the qualifying draw:

• Eudice Chong
• Dalila Jakupović
• Lisa Pigato
• Sapfo Sakellaridi
• Oana Georgeta Simion
• Lulu Sun
• Anna Turati
• Tara Würth

• Elisabetta Cocciaretto def. Ylena In-Albon, 6–2, 6–2

• Alena Fomina-Klotz / Dalila Jakupović def. Eudice Chong / Liang En-shuo, 6–1, 6–4

• 2022 Città di Grado Tennis Cup at ITFtennis.com