2-Oxohistidine is a derivative of histidine damaged by reactive oxygen species. It is a biological marker for assessing protein modifications from oxidative stress.[1] In particular, it arises by iron-catalyzed reaction with hydrogen peroxide.[2]

References

  1. ^ Uchida K, Kawakishi S (1993). "2-Oxo-histidine as a novel biological marker for oxidatively modified proteins". FEBS Lett. 332 (3): 208–210. Bibcode:1993FEBSL.332..208U. doi:10.1016/0014-5793(93)80632-5. PMID 8405458.
  2. ^ Lee, Jin-Won; Helmann, John D. (2006). "The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation". Nature. 440 (7082): 363–367. doi:10.1038/nature04537. PMID 16541078.
Allikas: http://en.wikipedia.org/wiki/2-Oxohistidine
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