1H-LSD (N1-hexanoyl-lysergic acid diethylamide, SYN-L-027)[1] is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.[2]

See also

References

  1. ^ WO 2024028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
  2. ^ Brandt SD, Kavanagh PV, Gare S, Stratford A, Halberstadt AL (July 2024). "Analytical and behavioral characterization of 1-hexanoyl-LSD (1H-LSD)" (PDF). Drug Testing and Analysis. doi:10.1002/dta.3767. PMID 38965834.
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