The 15th Syracuse Grand Prix was a motor race, run to Formula One rules, held on 1 May 1966 at Syracuse Circuit, Sicily. The race was run over 56 laps of the circuit, and was won by British driver John Surtees in a Ferrari 312.

Jack Brabham, Vic Wilson and Denny Hulme all failed to post a time during practice, and lined up on the grid behind the last driver to post a time, André Wicky, whose time was 37.4 seconds slower than Surtees's pole time.^[1]

Pos	Driver	Entrant	Constructor	Time/Retired	Grid
1	John Surtees	SEFAC Ferrari	Ferrari	1.40:08.3	1
2	Lorenzo Bandini	SEFAC Ferrari	Ferrari	+ 24.6 s	2
3	David Hobbs	Reg Parnell (Racing)	Lotus-BRM	54 laps	7
4	Vic Wilson	Team Chamaco Collect	BRM	53 laps	11
5	Jo Bonnier	Rob Walker Racing Team	Brabham-BRM	52 laps	4
NC	Guy Ligier	Guy Ligier	Cooper-Maserati	39 laps - Ignition	5
Ret	Paul Hawkins	Reg Parnell (Racing)	Lotus-Climax		6
Ret	Jo Siffert	Rob Walker Racing Team	Cooper-Maserati	Driveshaft	3
Ret	Denny Hulme	Brabham Racing Organisation	Brabham-Climax	Engine	12
Ret	Jack Brabham	Brabham Racing Organisation	Brabham-Repco	Engine	10
DNS	Giancarlo Baghetti	Anglo-Suisse Racing Team	Lotus-Climax	Gearbox	8
DNS	André Wicky	André Wicky	Cooper-BRM	Battery[1]	9
DNS	Bob Anderson	DW Racing Enterprises	Brabham-Climax	Piston in practice	-
DNA	Roberto Bussinello	Alf Francis[1]	Cooper-ATS		-

• "The Grand Prix Who's Who", Steve Small, 1995.
• "Cooper Cars", Doug Nye. Motorbooks, 2003.
• Race results at www.motorsportmagazine.com [1]