19-Epivoacristine is an indole alkaloid found in different species of Tabernaemontana, such as Tabernaemontana dichotoma, as well as in Peschiera affinis.[1] It is also known as 20-epivoacangarine and 19-epi-voacangarine.[2]

Potential pharmacology

19-Epivoacristine may be a selective acetylcholinesterase (AChE) inhibitor in vitro.[3]

Chemistry

19-Epivoacristine can be prepared by potassium borohydride reduction of voacryptine.[4]

See also

References

  1. ^ Lemos TL, Andrade CH, Guimarães AM, Wolter-Filho W, Braz-Filho RF (1996). "19-Epivoacristine, an Iboga Alkaloid Isolated from Peschiera affinis". Journal of the Brazilian Chemical Society. 7 (2): 123–126. doi:10.5935/0103-5053.19960018.
  2. ^ "Tabernaemontana dichotoma Roxb.ex Wall". PhytoChemical Interactions DB (PCIDB).
  3. ^ Vieira IJ, Medeiros WL, Monnerat CS, Souza JJ, Mathias L, Braz-Filho R, Pinto AC, Sousa PM, Rezende CM, Epifanio Rde A (September 2008). "Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures" (PDF). Anais da Academia Brasileira de Ciências. 80 (3): 419–26. doi:10.1590/s0001-37652008000300003. PMID 18797794.
  4. ^ Manske RH (12 May 2014). The Alkaloids: Chemistry and Physiology. Elsevier. p. 83. ISBN 9781483221960.
Allikas: http://en.wikipedia.org/wiki/19-Epivoacristine
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