Events from the year 1649 in art.

• Rembrandt and Gerard Dou are painting during this year.

• 
  Velázquez - Portrait of Juan de Pareja
• 
  van Ruysdael - Ferry on a River
• 
  van der Neer - Landscape with Windmill
• 
  Portrait of Oliver Cromwell by Robert Walker

• Aert van der Neer - Landscape with Windmill (1647–49)
• Paulus Potter - A Young Bull and Two Cows in a Meadow
• Nicolas Poussin (some dates approximate)
  • The Holy Family
  • The Judgement of Solomon
  • Vision of St Paul
  • Two self-portraits
• David Ryckaert - Suffering of the Peasants
• Salomon van Ruysdael - Ferry on a River
• Diego Velázquez - Portrait of Juan de Pareja (approximate date)
• Robert Walker – Portrait of Oliver Cromwell

• January 12 - Jacques Carrey, French painter and draughtsman (died 1726)
• July 4 - William Lodge, English engraver and printmaker (died 1689)
• date unknown
  • Bon Boullogne, French painter (died 1717)
  • Elias van den Broeck (or Broek), Dutch artist (died 1708)
  • Paolo Antonio Paderna, Italian painter of the Baroque period born in Bologna (died 1708)
  • Hermione van Rijn, second child of Rembrandt and Saskia van Uylenburgh
  • Giovanni Stefano Robatto, Italian painter for churches in Genoa (died 1733)
  • Cristóbal de Villalpando, Mexican painter (died 1714)
  • Jan van der Brugge, Flemish Baroque painter and engraver (died 1699)

• January 22 - Alessandro Turchi, Italian painter (born 1578)
• April 1 - Juan Bautista Mayno, Spanish painter of the Baroque period (born 1569)
• June 18 - Juan Martínez Montañés, also known as el Dios de la Madera, Spanish sculptor (born 1568)
• June 20 - Maria Tesselschade Visscher, Dutch poet and engraver (born 1594)
• June 28 - Gioacchino Assereto, Italian painter, active in Genoa (born 1600)
• July 29 - David Teniers the Elder, Flemish painter (born 1582)
• August 16 - Henricus Hondius II, Dutch painter (born 1573)
• October - Isaac van Ostade, Dutch genre and landscape painter (born 1621)
• November 2 - Antonio Barbalonga, Italian painter (born 1600)
• date unknown
  • Jan Baptist Barbé, Flemish engraver (born 1578)
  • Paolo Antonio Barbieri, Italian painter who was the brother of Guercino (born 1603)
  • Aniella di Beltrano, Italian woman painter (born 1613)
  • Alfonso Boschi, Italian painter of the Baroque period, active mainly in Florence (born 1615)
  • Sebastiano Brunetti, Italian painter active in his native Bologna (born unknown)
  • Andrea Camassei, Italian painter active in Rome under the patronage of the Barberini (born 1602)
  • Castellino Castello, Italian painter, active mainly in Genoa (born 1580)
  • Giovanni Battista Coriolano, Italian engraver (born 1590)
  • Juan de Zurbarán, Spanish Baroque painter (born 1620)
  • Cornelis Willemsz Eversdijck, Dutch portrait painter (born unknown)
  • Francesco Gessi, Italian painter of frescoes (born 1588)
  • Abraham Matthijs, Flemish Baroque painter (born 1581)
  • Hendrik van Steenwijk II, Dutch Baroque painter of architectural interiors (born 1580)
• probable - Ludovicus Neefs, Flemish painter (born 1617)