Events from the year 1599 in art.

• July 23 - Caravaggio receives his first public commission for paintings.

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  Caravaggio, Basket of Fruit
• 
  Caravaggio, Judith Beheading Holofernes
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  Caravaggio, David and Goliath
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  Caravaggio, Narcissus

• Paul Bril – Mountain Scene (miniature)
• Caravaggio
  • Basket of Fruit
  • Judith Beheading Holofernes
  • David and Goliath
  • Narcissus
• Pieter Pietersz the Elder – Poor Parents, Rich Children
• Hendrick van Balen the Elder – The Judgement of Paris

• February 15 - Pope Alexander II, Papal patron of the arts commissioned architectural and sculptural works by Gianlorenzo Bernini (died 1667)
• March 22 – Anthony van Dyck, Flemish Baroque artist who became England's leading court painter (died 1641)
• June – Diego Velázquez, Spanish painter (died 1660)
• September 25 – Francesco Borromini (Francesco Castelli), prominent and influential Baroque architect in Rome (died 1667)
• November 30 – Andrea Sacchi, Italian painter of High Baroque Classicism (died 1661)
• December – Pieter van Laer, Dutch painter of genre scenes (died 1642)
• December 11 – Pieter Codde, Dutch painter of genre works (died 1678)
• date unknown
  • Francisco Collantes, Spanish Baroque era painter (died 1656)
  • Willem Cornelisz Duyster, Dutch painter from Amsterdam (died 1635)
  • Jan Miel, Flemish painter (died 1663)
  • Gerrit Reynst, Dutch merchant and art collector (died 1658)
  • Giovanni Battista Vanni, Italian painter of frescoes and engraver (died 1660)
  • Robert Walker – English portrait painter (died 1658)
• probable
  • Bartolommeo Coriolano, Italian engraver (died 1676)
  • Antioine Le Nain, French painter of the Le Nain family of painters (died 1648)

• October 27 - Gillis Coignet, painter (born 1540)
• date unknown
  • Alberto di Giovanni Alberti, Tuscan architect, wood carver and painter (born 1525)
  • Antoine Caron, French master glassmaker, illustrator, Mannerist painter and a master (teacher) at the School of Fontainebleau (born 1521)
  • Valerio Cioli, Italian sculptor (born 1529)
  • Gillis Coignet, Flemish painter (born 1542)
  • Wendel Dietterlin, German painter/architect, wrote treatise on the five orders entitled Architectura (1598) filled with Mannerist ornament (born 1550)
  • Giuseppe Meda, Italian painter, architect and hydraulics engineer (born c.1534)
  • Dominicus Lampsonius, Flemish poet and artist (born 1532)
  • Francesco Potenzano, Italian painter, poet, and promoter
  • Friedrich Sustris, Italian-born Dutch painter working in Bavaria (born c.1540)
  • Mayken Verhulst, Flemish miniaturist and watercolour painter (born 1518)
  • Pierre Woeiriot, French engraver, goldsmith, painter, sculptor and medallist (born 1532)